Latest Publications

Yin, M., Izadi, M., Tenghlin, K., Viennet, T., Zhai, L., Zheng, G., Arthanari, H., Dassama, L.M.K., and Orkin, S.H. Evolution of nanobodies specific for BCL11A. Proc. Natl. Acad. Sci. USA, Jan 17;120(3):e2218959120. doi: 10.1073/pnas.2218959120, 2023.

Shen, F., Zheng, G., Setegne, M., Tenglin, K., Izadi, M., Xie, H., Zhai, L., Orkin, S.H., and Dassama, L.M.K. A cell-permeant nanobody-based degrader that induces fetal hemoglobin. ACS Cent. Sci., 8, 12, 1695–1703, 2022.

Eagle, K., Harada, T., Kalfon, J., Perez, M.W., Heshmati, Y., Ewers, J., Koren, J.V., Herbert, Z.T., Dempster, J.M., Kugener, G., Paralkar, V.R., Lin, C.Y., Dharia, N.V., Stegmaier, K., Orkin, S.H., and Pimkin, M. Transcriptional plasticity drives leukemia immune escape. Blood Cancer Discov. 3:394-409, 2022. doi: 10.1158/2643-3230.BCD-21-0207.

Mehta, S., Buyanbat, A., Kai, Y., Karayel, O., Goldman, S.R., Seruggia, D., Zhang, K., Fujiwara, Y., Donovan, K.A., Zhu, Q., Yang, H., Nabet, B., Gray, N.S., Mann, M., Fischer, E.S., Adelman, K., and Orkin, S.H. Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells. Cell Chemical Biology, 29: 1273-1287, 2022. https://doi.org/10.1016/j.chembiol.2022.06.007.

Harada, T., Hesmati, Y., Kalfon, J., Ferrucio, J.X., Perez, M., Ewers, J., Engler, B.H., Kossenkov, A., Ellegast, J.M., Yi, J.S., Bowker, A., Zhu, Q., Eagle, K., Dempster, J.M., Kugener, G., Wickramasinghe, J., Herbert, Z.T., Li, C.Y, Koren, J.V., Weinstock, D.M., Paralkar, V.R., Nabet, B., Lin, C.Y., Dharia, N.V., Stegmaier, K., Orkin, S.H., and Pimkin, M. A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia. Genes Dev. 36: 368-389, 2022.

Cha, H.J., Uyan, O., Kai, Y., Liu. T., Zhu, Q., Tothova, Z., Botten, G.A., Xu, J., Yuan, G-C., Dekker, J., and Orkin, S.H. Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture. Nat Commun 12: 6241. doi.org/10.1038/s41467-021-26574-4. 2021.

Liu, N., Xu, S., Yao, Q., Zhu, Q., Kai, Y., Hsu, J.Y., Sakon, P., Pinello, L., Yuan, G-C., Bauer, D.E., and Orkin, S.H. Transcription factor competition at the g-globin promoters controls hemoglobin switching. Nat. Genet. 53: 511-520, 2021.

Canver, M.C., Lessard, S., Pinello, L., Ilbourdo, Y., Stern, E.N., Needleman, A.J., Galacteros, F., Brugnara, C., Kutlar, A., McKenzie, C., Reid, M., Chen, D.D., Das, P.P., Kurita, R., Nakamura, Y., Yuan, G-C., Lettre, G., Bauer, D.E., and Orkin, S.E. Variant-aware saturating mutagenesis using multiple nucleases identifies regulatory elements underlying trait-associations of the HBS1L-MYB intergenic region. Nature Genetics, 49: 625-634, 2017.

Canver, M.C., Smith, E.C., Sher, F., Pinello, L., Sanjana, N.E., Shalem, O., Chen, D., Schupp, P., Vinjamur, D.S., Garcia, S., Luc, S., Kurita, R., Nakamura, Y., Fujiwara, Y., Maeda, T., Yuan, G-C., Zhang, F.*, Orkin, S.H.*, and Bauer, D.E*. BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. Nature, 527: 192-197, 2015 (* Co-senior authors)

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